Progesterone Cream For Menopause and PMS

Welcome to Nutrition Breakthroughs.  If you’re looking for an effective insomnia remedy for menopause or pre-menopause, you’ve come to the right place. Soothe Natural Progesterone Cream has been replaced by Sleep Minerals II, due to the superior results it provides.  For help with falling asleep, sleeping more deeply, or getting back to sleep in the middle of the night, click here. Sleep Minerals II.

middle aged woman


PRODUCT BENEFITS: Are you in the time of life of premenopause or menopause? Have you ever experienced hot flashes, mood swings, insomnia, depression, weight gain, night sweats, water retention, fatigue, or food cravings? If so, you may have heard of some of the many remedies being offered to women for these symptoms, both natural and drug-based.  Out of all the offerings, natural progesterone cream has been proven to be one of the safest, most effective, doctor-recommended solutions.


I have been using 1/4 teaspoon of progesterone cream twice a day for 14 days now and notice the night sweats have disappeared and I don't feel so warm all the time. Thank you,

Susan - Los Angeles, CA.

I am applying the cream nightly. I did notice a difference and am sleeping much better. I get a good sleep and feel fine.  I feel as though the cream somehow made my skin clearer, the way I used to feel just before I would get my period -- kind of a burst of energy and well-being. I will keep using it because I do feel it has contributed to my overall feeling of well being.

D.B. - Falls Church, VA.

I was experiencing fatigue, loss of appetite, mood shifts, loss of energy, low blood pressure, dizziness, and had no strength at all. I had gone for many tests and still couldn’t figure out what was wrong. My periods were very painful and draining and I was at my wits end. I tried the progesterone cream inside my arms and it was like waving a magic wand over my body. I actually felt something shift IMMEDIATLEY. I was full of energy. I couldn’t believe how good I felt so quickly, I knew then that this was just what my body was missing and needed. I STRONGLY recommend this progesterone cream to anyone with similar symptoms.

M.S. - Clearwater, Florida

I am doing very well. I apply progesterone every morning and evening, and it really "fills in the holes in my body”-- that's what it feels like at least. I can handle restless sleep, insomnia, and aches with it. I had a big migraine a couple of weeks ago, but since then I have adjusted the amount I apply and I believe that has bettered it.

E.M.D. - Denmark


Dr. John R. Lee, M.D. explains more about this in his two books: “What Your Doctor May Not Tell You About Menopause” and “What Your Doctor May Not Tell You About Premenopause”.  A woman’s estrogen levels drop by only 40% to 60% at menopause which is just enough to stop the menstrual cycle -- but progesterone levels usually fall to near zero. 

In fact, many years prior to actual menopause, progesterone begins a steep decline, eventually leading to a progesterone deficiency.  This is due to the lessening of eggs in the ovaries, excess toxic estrogen-like substances in the environment, and having less vegetables and more processed foods in the diet.

Environmental toxins have estrogenic effects which add to the imbalance, such as synthetic chemicals, pesticides, plastics, car exhaust, soaps, detergents, and hormones in meats. A state of “estrogen dominance” can take place where estrogen becomes the dominant hormone in the body.  Estrogen is potent and is potentially toxic when not balanced by adequate progesterone.

It is interesting to note that many of the symptoms of PMS correlate with estrogen dominance as well, such as water retention, breast swelling, headaches, mood swings and insomnia. Thus, the likely cause of pre-menopause and menopause symptoms, and even PMS, is an excess of estrogen and a lack of progesterone.

Supplementing with a natural progesterone cream provides a balancing and tempering effect on the estrogen.  It creates harmony in the body once more and brings calming, stabilizing relief.*


J. Hanley, M.D. -- “Natural progesterone has been an important, exciting and innovative addition to my practice in women's health care. It is a strategic part of my treatment of menopause, PMS, osteoporosis, irregular menstruation, and more.  I no longer have use for the unnatural hormone drugs that cause so many unnecessary side effects. I am grateful to discover that natural progesterone helps to safely restore healthy hormone balance.”

C. Northrup, M.D. -- “Natural progesterone has no serious side effects at the usual doses. In some cases, a woman will need only natural progesterone to relieve all of her menopause symptoms.  This is possible because progesterone is a precursor molecule that the body can use to produce other hormones.”

“Natural progesterone can also be effective in reversing bone loss when used in combination with nutrition and exercise. It can alleviate the symptoms of both progesterone deficiency and estrogen excess, restoring the body's balance. I've been recommending it for years.”

J. R. Lee, M.D. -- "I recommend creams that contain 450 to 500 mg. of progesterone per ounce, which is 3% by volume. Healthy progesterone levels are 20 to 30 mg. per day, produced during the last half of the menstrual cycle (the two weeks prior to menstruation). This means that about one quarter teaspoon of progesterone cream daily would provide the 20 milligrams. The skin cream method is far better than oral progesterone tablets because 80% to 90% of the oral dose is lost through the liver."


The results of a placebo-controlled study were published in the Journal of Obstetrics and Gynecology.  It evaluated the effectiveness of progesterone cream in relieving the menopause symptoms of hot flashes. The study lasted for one year.  Results: In the treatment group, 25 of the 30 women (83 percent) noted improvement or resolution of hot flashes and night sweats.  On the other hand, only 5 of the 26 women in the placebo group (19 percent) reported any improvement in their symptoms. The researchers concluded that progesterone cream provides effective relief for hot flashes and night sweats.

(Reference: Leonetti H.B., "Transdermal progesterone cream for hot flash symptoms and postmenopausal bone loss."  Obstetrics & Gynecology, August 1999).


PREMENOPAUSAL WOMEN: Use for approximately two weeks per month.  Ideal progesterone production is about 20 milligrams per day between days 12 to 26 of the cycle (with day 1 being the first day of the period).  Use 1/4 teaspoon of the cream each day between days 12 and 26 to reach normal levels (1/8 teaspoon with each use; about the size of a pea).  Stop using the cream a couple of days before your period starts to allow for normal menstruation. 

WHERE TO APPLY: Apply the cream to the palms of the hands, the face and neck, the upper chest and breast, the inside of the arms, behind the knees, or on the forehead or temples to help with sleep.  Rotate locations with each application. Use in the evening just before bed (as the cream is calming and produces better sleep), and also in the morning after showering.

MENOPAUSAL WOMEN who are not taking hormone replacement drugs: Select a dosage schedule based on the calendar month.  The cream can be applied over a 3-week period and then discontinued until the next month. Take at least one week off per month.  Apply as above.

FOR PMS: Many of the symptoms of PMS correlate with those of estrogen dominance, such as water retention, breast swelling, headaches, mood swings, loss of interest in sex, and trouble sleeping. Day 1 of the cycle is the first day of the period. With this in mind, count to day 11 or 12 and start using the cream. Use bigger dabs of cream in the last 3 or 4 days of use. Cease using it a day or two before your period starts.

FOR INSOMNIA: Apply a dab of progesterone cream to the forehead or temples and rub in very well.  If you wake up during the night and are unable to fall back asleep, rub some more in. 

NOTE: The right dose is the one that works best to relieve your symptoms.  It's fine to experiment with it. You can also apply the cream directly to problem or painful areas. There are no side effects, except for a bit of sleepiness if you take too much. If this occurs, reduce the dose until the sleepiness disappears.

HOW LONG WILL IT TAKE? At the recommended dosage, a progesterone-deficient woman who begins using the cream will find that in three to four months, the progesterone in her body will reach the optimum, symptom-free levels. Many women experience relief right away, and with consistent use, the benefits will increase over time.*

SIZE: 2.1 ounce jar. This generally lasts 1 to 2 months. Each jar contains 1000 mg. of human-identical progesterone.  One rounded 1/4 teaspoon contains approximately 30 mg. of progesterone.

INGREDIENTS: Purified water, plant derived coconut and palm oil, emulsifying wax, stearic acid, cetyl alcohol, progesterone, mixed tocopherols, glycerin, and potassium sorbate.  Free of chemicals and synthetic ingredients.

ABOUT THIS CREAM: After testing six different brands of progesterone cream, Nutrition Breakthroughs highly recommends Soothe Natural Progesterone Cream. It simply works the best, has the purest ingredients and has no side effects. The progesterone is natural and is identical to what the female body produces.


1. “What Your Doctor May Not Tell You About Menopause -- The Breakthrough Book on Natural Progesterone” by John R. Lee, M.D. and Virginia Hopkins.

2. “What Your Doctor May Not Tell You About Premenopause -- Balance Your Hormones and Your Life From Thirty to Fifty” by John R. Lee, M.D., Jesse Hanley, M.D., and Virginia Hopkins.


**The term "estrogen dominance" was created by Dr. Lee, based on his extensive research and 30 years of treating women. He is to be commended for his service to the bettered health of all women.  

This information is provided for educational purposes only and is not intended to be used as medical advice. It is always best to consult with your natural health care practitioner or medical doctor prior to using nutritional supplements. All women should obtain regular gynecological check-ups and physical exams regardless of what nutritional, hormonal or medical products they are using.

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These statements have not been evaluated by the Food and Drug Administration.  The nutrients and products discussed here are not intended to diagnose, treat, cure, or prevent any disease.  Site last updated 7/15/17.